Molecular basis for differential sensitivity of KCNQ and IKs channels to the cognitive enhancer XE991
HS Wang, BS Brown, D McKinnon, IS Cohen - Molecular Pharmacology, 2000 - Elsevier
Channels formed by coassembly of the KCNQ1 (KvLQT1) subunit and the minK subunit
underlie slowly activating cardiac delayed rectifier (I Ks) in the heart, whereas two other
members of the KCNQ channel family, KCNQ2 and KCNQ3, coassemble to underlie the M
current in the nervous system. Because of their important physiological function, KCNQ
channels have potential as drug targets, and an understanding of possible mechanisms that
would enable tissue-specific targeting of these channels will be of significant value to drug …
underlie slowly activating cardiac delayed rectifier (I Ks) in the heart, whereas two other
members of the KCNQ channel family, KCNQ2 and KCNQ3, coassemble to underlie the M
current in the nervous system. Because of their important physiological function, KCNQ
channels have potential as drug targets, and an understanding of possible mechanisms that
would enable tissue-specific targeting of these channels will be of significant value to drug …