Two new potent neurotransmitter release enhancers, 10, 10-bis (4-pyridinylmethyl)-9 (10H)-anthracenone and 10, 10-bis (2-fluoro-4-pyridinylmethyl)-9 (10H) …
R Zaczek, RJ Chorvat, JA Saye… - The Journal of …, 1998 - Elsevier
ABSTRACT Linopirdine (3, 3-bis (4-pyridinylmethyl)-1-phenylindolin-2-one, DUP996) is an
extensively studied representative of a class of cognition enhancing compounds that
increase the evoked release of neurotransmitters. Recent studies suggest that these agents
act through the blockade of specific K+ channels. We have recently identified more potent
anthracenone analogs of linopirdine: 10, 10-bis (4-pyridinylmethyl)-9 (10H)-anthracenone
(XE991) and 10, 10-bis (2-fluoro-4-pyridinylmethyl)-9 (10H)-anthracenone (DMP 543) …
extensively studied representative of a class of cognition enhancing compounds that
increase the evoked release of neurotransmitters. Recent studies suggest that these agents
act through the blockade of specific K+ channels. We have recently identified more potent
anthracenone analogs of linopirdine: 10, 10-bis (4-pyridinylmethyl)-9 (10H)-anthracenone
(XE991) and 10, 10-bis (2-fluoro-4-pyridinylmethyl)-9 (10H)-anthracenone (DMP 543) …
