Commentary on “Integrative genomic analyses reveal an androgen-driven somatic alteration landscape in early-onset prostate cancer.” Weischenfeldt J, Simon R …
AF Olumi - Urologic Oncology: Seminars and Original …, 2014 - Elsevier
Early-onset prostate cancer (EO-PCA) represents the earliest clinical manifestation of
prostate cancer. To compare the genomic alteration landscapes of EO-PCA with
“classical”(elderly-onset) PCA, we performed deep sequencing-based genomics analyses in
11 tumors diagnosed at young age, and pursued comparative assessments with seven
elderly-onset PCA genomes. Remarkable age-related differences in structural
rearrangement (SR) formation became evident, suggesting distinct disease …
prostate cancer. To compare the genomic alteration landscapes of EO-PCA with
“classical”(elderly-onset) PCA, we performed deep sequencing-based genomics analyses in
11 tumors diagnosed at young age, and pursued comparative assessments with seven
elderly-onset PCA genomes. Remarkable age-related differences in structural
rearrangement (SR) formation became evident, suggesting distinct disease …