Diseases of pulmonary surfactant homeostasis
JA Whitsett, SE Wert, TE Weaver - Annual Review of Pathology …, 2015 - annualreviews.org
Advances in physiology and biochemistry have provided fundamental insights into the role
of pulmonary surfactant in the pathogenesis and treatment of preterm infants with respiratory
distress syndrome. Identification of the surfactant proteins, lipid transporters, and
transcriptional networks regulating their expression has provided the tools and insights
needed to discern the molecular and cellular processes regulating the production and
function of pulmonary surfactant prior to and after birth. Mutations in genes regulating …
of pulmonary surfactant in the pathogenesis and treatment of preterm infants with respiratory
distress syndrome. Identification of the surfactant proteins, lipid transporters, and
transcriptional networks regulating their expression has provided the tools and insights
needed to discern the molecular and cellular processes regulating the production and
function of pulmonary surfactant prior to and after birth. Mutations in genes regulating …
