[HTML][HTML] HIV-1 gp41 envelope IgA is frequently elicited after transmission but has an initial short response half-life
NL Yates, AR Stacey, TL Nolen, NA Vandergrift… - Mucosal …, 2013 - Elsevier
Prevention of HIV-1 transmission at mucosal surfaces will likely require durable pre-existing
mucosal anti-HIV-1 antibodies (Abs). Defining the ontogeny, specificities and potentially
protective nature of the initial mucosal virus-specific B-cell response will be critical for
understanding how to induce protective Ab responses by vaccination. Genital fluids from
patients within the earliest stages of acute HIV-1 infection (Fiebig I–VI) were examined for
multiple anti-HIV specificities. Gp41 (but not gp120) Env immunoglobulin (Ig) A Abs were …
mucosal anti-HIV-1 antibodies (Abs). Defining the ontogeny, specificities and potentially
protective nature of the initial mucosal virus-specific B-cell response will be critical for
understanding how to induce protective Ab responses by vaccination. Genital fluids from
patients within the earliest stages of acute HIV-1 infection (Fiebig I–VI) were examined for
multiple anti-HIV specificities. Gp41 (but not gp120) Env immunoglobulin (Ig) A Abs were …