Bronchorelaxation of the human bronchi by CFTR activators
C Norez, C Jayle, F Becq, C Vandebrouck - Pulmonary pharmacology & …, 2014 - Elsevier
The airway functions are profoundly affected in many diseases including asthma, COPD and
cystic fibrosis (CF). CF the most common lethal autosomal recessive genetic disease is
caused by mutations of the CFTR (Cystic Fibrosis transmembrane Conductance Regulator)
gene, which normally encodes a multifunctional and integral membrane cAMP regulated
and ATP gated Cl− channel expressed in airway epithelial cells. Using human lung tissues
obtained from patients undergoing surgery for lung cancer, we demonstrated that CFTR …
cystic fibrosis (CF). CF the most common lethal autosomal recessive genetic disease is
caused by mutations of the CFTR (Cystic Fibrosis transmembrane Conductance Regulator)
gene, which normally encodes a multifunctional and integral membrane cAMP regulated
and ATP gated Cl− channel expressed in airway epithelial cells. Using human lung tissues
obtained from patients undergoing surgery for lung cancer, we demonstrated that CFTR …