The anti-inflammatory action of methotrexate is not mediated by lymphocyte apoptosis, but by the suppression of activation and adhesion molecules
A Johnston, JE Gudjonsson, H Sigmundsdottir… - Clinical …, 2005 - Elsevier
Low-dose methotrexate (MTX) is an established and highly effective treatment for severe
psoriasis and rheumatoid arthritis; however, its mechanism of action remains unclear. We
investigated the effects of low-dose MTX on antigen-stimulated peripheral blood
mononuclear cells and explored through which cellular pathways these effects are
mediated. We show that MTX caused a dose-dependent suppression of T cell activation and
adhesion molecule expression, and this was not due to lymphocyte apoptosis. The …
psoriasis and rheumatoid arthritis; however, its mechanism of action remains unclear. We
investigated the effects of low-dose MTX on antigen-stimulated peripheral blood
mononuclear cells and explored through which cellular pathways these effects are
mediated. We show that MTX caused a dose-dependent suppression of T cell activation and
adhesion molecule expression, and this was not due to lymphocyte apoptosis. The …