[HTML][HTML] Standards of care and novel approaches in the management of glioblastoma multiforme
AF Hottinger, R Stupp, K Homicsko - Chinese journal of cancer, 2014 - ncbi.nlm.nih.gov
AF Hottinger, R Stupp, K Homicsko
Chinese journal of cancer, 2014•ncbi.nlm.nih.govGlioblastoma multiforme (GBM) is the most common malignant primary brain tumor in adults.
Standard therapeutic approaches provide modest improvement in the progression-free and
overall survival, necessitating the investigation of novel therapies. We review the standard
treatment options for GBM and evaluate the results obtained in clinical trials for promising
novel approaches, including the inhibition of angiogenesis, targeted approaches against
molecular pathways, immunotherapies, and local treatment with low voltage electric fields.
Standard therapeutic approaches provide modest improvement in the progression-free and
overall survival, necessitating the investigation of novel therapies. We review the standard
treatment options for GBM and evaluate the results obtained in clinical trials for promising
novel approaches, including the inhibition of angiogenesis, targeted approaches against
molecular pathways, immunotherapies, and local treatment with low voltage electric fields.
Abstract
Glioblastoma multiforme (GBM) is the most common malignant primary brain tumor in adults. Standard therapeutic approaches provide modest improvement in the progression-free and overall survival, necessitating the investigation of novel therapies. We review the standard treatment options for GBM and evaluate the results obtained in clinical trials for promising novel approaches, including the inhibition of angiogenesis, targeted approaches against molecular pathways, immunotherapies, and local treatment with low voltage electric fields.
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