[HTML][HTML] Acquisition of temozolomide chemoresistance in gliomas leads to remodeling of mitochondrial electron transport chain
CR Oliva, SE Nozell, A Diers, SG McClugage… - Journal of Biological …, 2010 - ASBMB
Temozolomide (TMZ) is an oral alkylating agent used for the treatment of high-grade
gliomas. Acquired chemoresistance is a severe limitation to this therapy with more than 90%
of recurrent gliomas showing no response to a second cycle of chemotherapy. Efforts to
better understand the underlying mechanisms of acquired chemoresistance to TMZ and
potential strategies to overcome chemoresistance are, therefore, critically needed. TMZ
methylates nuclear DNA and induces cell death; however, the impact on mitochondria DNA …
gliomas. Acquired chemoresistance is a severe limitation to this therapy with more than 90%
of recurrent gliomas showing no response to a second cycle of chemotherapy. Efforts to
better understand the underlying mechanisms of acquired chemoresistance to TMZ and
potential strategies to overcome chemoresistance are, therefore, critically needed. TMZ
methylates nuclear DNA and induces cell death; however, the impact on mitochondria DNA …