[HTML][HTML] New role for Kruppel-like factor 14 as a transcriptional activator involved in the generation of signaling lipids

TM De Assuncao, G Lomberk, S Cao, U Yaqoob… - Journal of Biological …, 2014 - ASBMB
Sphingosine kinase 1 (SK1) is an FGF-inducible gene responsible for generation of
sphingosine-1-phosphate, a critical lipid signaling molecule implicated in diverse
endothelial cell functions. In this study, we identified SK1 as a target of the canonical
FGF2/FGF receptor 1 activation pathway in endothelial cells and sought to identify novel
transcriptional pathways that mediate lipid signaling. Studies using the 1.9-kb SK1 promoter
and deletion mutants revealed that basal and FGF2-stimulated promoter activity occurred …