[HTML][HTML] Hepatic autophagy is suppressed in the presence of insulin resistance and hyperinsulinemia: inhibition of FoxO1-dependent expression of key autophagy …

HY Liu, J Han, SY Cao, T Hong, D Zhuo, J Shi… - Journal of Biological …, 2009 - ASBMB
Autophagy is essential for maintaining both survival and health of cells. Autophagy is
normally suppressed by amino acids and insulin. It is unclear what happens to the
autophagy activity in the presence of insulin resistance and hyperinsulinemia. In this study,
we examined the autophagy activity in the presence of insulin resistance and
hyperinsulinemia and the associated mechanism. Insulin resistance and hyperinsulinemia
were induced in mice by a high fat diet, followed by measurements of autophagy markers …