Reversibility of hyperglycaemia and islet abnormalities in the high fat-fed female ZDF rat model of type 2 diabetes
J Teague, A Gyte, JE Peel, KC Young… - … of Pharmacological and …, 2011 - Elsevier
INTRODUCTION: We characterised the development of Type 2 diabetes and associated
changes in islet appearance in female ZDF rats and explored its suitability for studies with
novel therapeutic agents. METHODS: Female ZDF rats were either chow or high fat (60%)
fed for up to 36days and blood glucose and plasma insulin concentration measured.
Additionally, we restored two groups of rats back to chow diet after ten and nineteen days of
high fat feeding to determine the reversibility. Finally, two other groups of high fat-fed …
changes in islet appearance in female ZDF rats and explored its suitability for studies with
novel therapeutic agents. METHODS: Female ZDF rats were either chow or high fat (60%)
fed for up to 36days and blood glucose and plasma insulin concentration measured.
Additionally, we restored two groups of rats back to chow diet after ten and nineteen days of
high fat feeding to determine the reversibility. Finally, two other groups of high fat-fed …