The WNK kinase network regulating sodium, potassium, and blood pressure
EJ Hoorn, JH Nelson, JA McCormick… - Journal of the American …, 2011 - journals.lww.com
The relationship between renal salt handling and hypertension is intertwined historically.
The discovery of WNK kinases (With No lysine= K) now offers new insight to this relationship
because WNKs are a crucial molecular pathway connecting hormones such as angiotensin
II and aldosterone to renal sodium and potassium transport. To fulfill this task, the WNKs also
interact with other important kinases, including serum and glucocorticoid-regulated kinase 1,
STE20/SPS1-related, proline alanine-rich kinase, and oxidative stress responsive protein …
The discovery of WNK kinases (With No lysine= K) now offers new insight to this relationship
because WNKs are a crucial molecular pathway connecting hormones such as angiotensin
II and aldosterone to renal sodium and potassium transport. To fulfill this task, the WNKs also
interact with other important kinases, including serum and glucocorticoid-regulated kinase 1,
STE20/SPS1-related, proline alanine-rich kinase, and oxidative stress responsive protein …