[HTML][HTML] SPAK isoforms and OSR1 regulate sodium-chloride co-transporters in a nephron-specific manner
PR Grimm, TK Taneja, J Liu, R Coleman… - Journal of Biological …, 2012 - ASBMB
STE20/SPS-1-related proline-alanine-rich protein kinase (SPAK) and oxidative stress-
related kinase (OSR1) activate the potassium-dependent sodium-chloride co-transporter,
NKCC2, and thiazide-sensitive sodium-chloride cotransporter, NCC, in vitro, and both co-
localize with a kinase regulatory molecule, Cab39/MO25α, at the apical membrane of the
thick ascending limb (TAL) and distal convoluted tubule (DCT). Yet genetic ablation of SPAK
in mice causes a selective loss of NCC function, whereas NKCC2 becomes …
related kinase (OSR1) activate the potassium-dependent sodium-chloride co-transporter,
NKCC2, and thiazide-sensitive sodium-chloride cotransporter, NCC, in vitro, and both co-
localize with a kinase regulatory molecule, Cab39/MO25α, at the apical membrane of the
thick ascending limb (TAL) and distal convoluted tubule (DCT). Yet genetic ablation of SPAK
in mice causes a selective loss of NCC function, whereas NKCC2 becomes …