[HTML][HTML] A novel Ste20-related proline/alanine-rich kinase (SPAK)-independent pathway involving calcium-binding protein 39 (Cab39) and serine threonine kinase …
J Ponce-Coria, N Markadieu, TM Austin… - Journal of Biological …, 2014 - ASBMB
Na+-dependent chloride cotransporters (NKCC1, NKCC2, and NCC) are activated by
phosphorylation to play critical roles in diverse physiological responses, including renal salt
balance, hearing, epithelial fluid secretion, and volume regulation. Serine threonine kinase
WNK4 (With No K= lysine member 4) and members of the Ste20 kinase family, namely
SPAK and OSR1 (Ste20-related proline/alanine-rich kinase, Oxidative stress-responsive
kinase) govern phosphorylation. According to present understanding, WNK4 phosphorylates …
phosphorylation to play critical roles in diverse physiological responses, including renal salt
balance, hearing, epithelial fluid secretion, and volume regulation. Serine threonine kinase
WNK4 (With No K= lysine member 4) and members of the Ste20 kinase family, namely
SPAK and OSR1 (Ste20-related proline/alanine-rich kinase, Oxidative stress-responsive
kinase) govern phosphorylation. According to present understanding, WNK4 phosphorylates …