Human CD8+ T cells display a differential ability to undergo cytokine-driven bystander activation
ENB Ghanem, SEF D'Orazio - Cellular immunology, 2011 - Elsevier
A subset of CD44hiCD8+ T cells in some, but not all mice, can be induced to rapidly secrete
IFNγ during infection with Listeria monocytogenes. This response is dependent on the
presence of both IL-12 and IL-18 and does not require engagement of the T cell receptor. In
this study, we demonstrate that human CD8+ T cells also vary widely in their ability to
secrete IFNγ within 15h of either Listeria infection or cytokine stimulation. The magnitude of
the rapid IFNγ response correlated more closely with the intrinsic responsiveness of the T …
IFNγ during infection with Listeria monocytogenes. This response is dependent on the
presence of both IL-12 and IL-18 and does not require engagement of the T cell receptor. In
this study, we demonstrate that human CD8+ T cells also vary widely in their ability to
secrete IFNγ within 15h of either Listeria infection or cytokine stimulation. The magnitude of
the rapid IFNγ response correlated more closely with the intrinsic responsiveness of the T …