A case for regulatory B cells in controlling the severity of autoimmune-mediated inflammation in experimental autoimmune encephalomyelitis and multiple sclerosis
Multiple sclerosis (MS) is considered to be a T cell-mediated autoimmune disease that
results in the presence of inflammatory lesions/plaques associated with mononuclear cell
infiltrates, demyelination and axonal damage within the central nervous system (CNS). To
date, FDA approved therapies in MS are thought to largely function by modulation of the
immune response. Since autoimmune responses require many arms of the immune system,
the direct cellular mechanisms of action of MS therapeutics are not definitively known. The …
results in the presence of inflammatory lesions/plaques associated with mononuclear cell
infiltrates, demyelination and axonal damage within the central nervous system (CNS). To
date, FDA approved therapies in MS are thought to largely function by modulation of the
immune response. Since autoimmune responses require many arms of the immune system,
the direct cellular mechanisms of action of MS therapeutics are not definitively known. The …
