Regulatory T cells in autoimmune neuroinflammation

M Kleinewietfeld, DA Hafler - Immunological reviews, 2014 - Wiley Online Library
Immunological reviews, 2014Wiley Online Library
Regulatory T cells are the central element for the maintenance of peripheral tolerance.
Several subtypes of regulatory T (Treg) cells have been described, and most of them belong
to the CD 4+ T‐helper (Th) cell lineage. These specific subtypes can be discriminated
according to phenotype and function. Forkhead box protein 3 (FoxP3)‐expressing natural
Treg cells (Tregs) and IL‐10‐producing, T‐regulatory type 1 cells (Tr1) are the best‐studied
types of CD 4+ regulatory T cells in humans and experimental animal models. It was shown …
Summary
Regulatory T cells are the central element for the maintenance of peripheral tolerance. Several subtypes of regulatory T (Treg) cells have been described, and most of them belong to the CD4+ T‐helper (Th) cell lineage. These specific subtypes can be discriminated according to phenotype and function. Forkhead box protein 3 (FoxP3)‐expressing natural Treg cells (Tregs) and IL‐10‐producing, T‐regulatory type 1 cells (Tr1) are the best‐studied types of CD4+ regulatory T cells in humans and experimental animal models. It was shown that they play a crucial role during autoimmune neuroinflammation. Both cells types seem to be particularly important for multiple sclerosis (MS). Here, we discuss the role of CD4+ regulatory T cells in autoimmune neuroinflammation with an emphasis on Tregs and Tr1 cells in MS.
Wiley Online Library