[HTML][HTML] Metabolism of myeloperoxidase-derived 2-chlorohexadecanal
KR Wildsmith, CJ Albert, DS Anbukumar… - Journal of Biological …, 2006 - ASBMB
Numerous studies have suggested relationships between myeloperoxidase (MPO),
inflammation, and atherosclerosis. MPO-derived reactive chlorinating species attack
membrane plasmalogens releasing α-chloro fatty aldehydes including 2-chlorohexadecanal
(2-ClHDA), which have been found to accumulate in activated neutrophils, activated
monocytes, infarcted myocardium and human atheromas. The present study employed
synthetically prepared 2-Cl-[3 H]-HDA as well as stable isotope-labeled 2-ClHDA to …
inflammation, and atherosclerosis. MPO-derived reactive chlorinating species attack
membrane plasmalogens releasing α-chloro fatty aldehydes including 2-chlorohexadecanal
(2-ClHDA), which have been found to accumulate in activated neutrophils, activated
monocytes, infarcted myocardium and human atheromas. The present study employed
synthetically prepared 2-Cl-[3 H]-HDA as well as stable isotope-labeled 2-ClHDA to …