[HTML][HTML] Myeloperoxidase-derived reactive chlorinating species from human monocytes target plasmalogens in low density lipoprotein
AK Thukkani, CJ Albert, KR Wildsmith… - Journal of Biological …, 2003 - ASBMB
A role for myeloperoxidase (MPO) in atherosclerosis has received considerable attention
recently. To identify potential chlorinated lipid products in human low density lipoprotein
(LDL), studies were designed to demonstrate that MPO-derived reactive chlorinating species
(RCS) target the plasmalogen pool of LDL isolated from peripheral human blood in vitro.
The vinyl ether bond of LDL plasmalogens was targeted by MPO-derived RCS, resulting in
the release of the 16-and 18-carbon-containing α-chloro fatty aldehydes, 2 …
recently. To identify potential chlorinated lipid products in human low density lipoprotein
(LDL), studies were designed to demonstrate that MPO-derived reactive chlorinating species
(RCS) target the plasmalogen pool of LDL isolated from peripheral human blood in vitro.
The vinyl ether bond of LDL plasmalogens was targeted by MPO-derived RCS, resulting in
the release of the 16-and 18-carbon-containing α-chloro fatty aldehydes, 2 …