The PGC-1α-dependent pathway of mitochondrial biogenesis is upregulated in type I endometrial cancer
Biochemical and biophysical research communications, 2009•Elsevier
PGC-1α-dependent pathway of mitochondrial biogenesis was investigated for the first time
in type I endometrial cancer and in normal endometrium. In cancer endometrial tissue the
citrate synthase activity, the mitochondrial DNA content and the TFAM level were found
doubled compared to control endometrial tissue. Moreover, a 1.6-and 1.8-fold increase,
respectively, of NRF-1 and PGG-1α expression was found. This study demonstrates, for the
first time, that the increased mitochondrial biogenesis in type I endometrial cancer is …
in type I endometrial cancer and in normal endometrium. In cancer endometrial tissue the
citrate synthase activity, the mitochondrial DNA content and the TFAM level were found
doubled compared to control endometrial tissue. Moreover, a 1.6-and 1.8-fold increase,
respectively, of NRF-1 and PGG-1α expression was found. This study demonstrates, for the
first time, that the increased mitochondrial biogenesis in type I endometrial cancer is …
PGC-1α-dependent pathway of mitochondrial biogenesis was investigated for the first time in type I endometrial cancer and in normal endometrium. In cancer endometrial tissue the citrate synthase activity, the mitochondrial DNA content and the TFAM level were found doubled compared to control endometrial tissue. Moreover, a 1.6- and 1.8-fold increase, respectively, of NRF-1 and PGG-1α expression was found. This study demonstrates, for the first time, that the increased mitochondrial biogenesis in type I endometrial cancer is associated to the upregulation of PGC-1α signalling pathway.
Elsevier
