The role of dysfunctional HDL in atherosclerosis
This review focuses on HDL function in modulating LDL oxidation and LDL-induced
inflammation. Dysfunctional HDL has been identified in animal models and humans with
chronic inflammatory diseases including atherosclerosis. The loss of antiinflammatory
function correlated with a loss of function in reverse cholesterol transport. In animal models
and perhaps in humans, dysfunctional HDL can be improved by apoA-I mimetic peptides
that bind oxidized lipids with high affinity.
inflammation. Dysfunctional HDL has been identified in animal models and humans with
chronic inflammatory diseases including atherosclerosis. The loss of antiinflammatory
function correlated with a loss of function in reverse cholesterol transport. In animal models
and perhaps in humans, dysfunctional HDL can be improved by apoA-I mimetic peptides
that bind oxidized lipids with high affinity.
