Beyond the aryl hydrocarbon receptor: pathway interactions in the hepatotoxicity of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin and related compounds
KA Fader, TR Zacharewski - Current opinion in toxicology, 2017 - Elsevier
Abstract 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) is the prototypical ligand for a group
of environmental halogenated aromatic hydrocarbon contaminants which elicit
hepatotoxicity and other toxic responses through activation of the aryl hydrocarbon receptor
(AhR). Despite the conservation of the AhR and its signaling pathway, TCDD-elicited
differential gene expression networks are species-specific, consistent with differences in
sensitivity and toxic responses between species. This review integrates gene expression …
of environmental halogenated aromatic hydrocarbon contaminants which elicit
hepatotoxicity and other toxic responses through activation of the aryl hydrocarbon receptor
(AhR). Despite the conservation of the AhR and its signaling pathway, TCDD-elicited
differential gene expression networks are species-specific, consistent with differences in
sensitivity and toxic responses between species. This review integrates gene expression …
