The NHLBI LAM registry: prognostic physiologic and radiologic biomarkers emerge from a 15-year prospective longitudinal analysis
N Gupta, HS Lee, JH Ryu, AM Taveira-DaSilva… - Chest, 2019 - Elsevier
Background The natural history of lymphangioleiomyomatosis (LAM) is mainly derived from
retrospective cohort analyses, and it remains incompletely understood. A National Institutes
of Health LAM Registry was established to define the natural history and identify prognostic
biomarkers that can help guide management and decision-making in patients with LAM.
Methods A linear mixed effects model was used to compute the rate of decline of FEV 1 and
to identify variables affecting FEV 1 decline among 217 registry patients who enrolled from …
retrospective cohort analyses, and it remains incompletely understood. A National Institutes
of Health LAM Registry was established to define the natural history and identify prognostic
biomarkers that can help guide management and decision-making in patients with LAM.
Methods A linear mixed effects model was used to compute the rate of decline of FEV 1 and
to identify variables affecting FEV 1 decline among 217 registry patients who enrolled from …
