Complement, infection, and autoimmunity
P Conigliaro, P Triggianese, E Ballanti… - Current Opinion in …, 2019 - journals.lww.com
Current Opinion in Rheumatology, 2019•journals.lww.com
The relationship between the complement system and autoimmunity appears paradoxical as
both the deficiency and the activation contribute to inducing autoimmune diseases. In these
conditions, the presence of complement deposition in affected tissues, decreased levels of
complement proteins, and high levels of complement activation fragments in the blood and
vessels have been documented.
both the deficiency and the activation contribute to inducing autoimmune diseases. In these
conditions, the presence of complement deposition in affected tissues, decreased levels of
complement proteins, and high levels of complement activation fragments in the blood and
vessels have been documented.
Summary
The relationship between the complement system and autoimmunity appears paradoxical as both the deficiency and the activation contribute to inducing autoimmune diseases. In these conditions, the presence of complement deposition in affected tissues, decreased levels of complement proteins, and high levels of complement activation fragments in the blood and vessels have been documented.
Lippincott Williams & Wilkins