[HTML][HTML] Smoking and osteoarthritis: differential effect of nicotine on human chondrocyte glycosaminoglycan and collagen synthesis

L Gullahorn, L Lippiello, R Karpman - Osteoarthritis and cartilage, 2005 - Elsevier
L Gullahorn, L Lippiello, R Karpman
Osteoarthritis and cartilage, 2005Elsevier
Anecdotal suggestions and retrospective studies indicate an inverse relationship between
the incidence of osteoarthritis and individuals who smoke. As a possible explanation, our
studies confirm that nicotine upregulates glycosaminoglycan and collagen synthetic activity
of articular chondrocytes at physiological levels seen in individuals who smoke.
Anecdotal suggestions and retrospective studies indicate an inverse relationship between the incidence of osteoarthritis and individuals who smoke. As a possible explanation, our studies confirm that nicotine upregulates glycosaminoglycan and collagen synthetic activity of articular chondrocytes at physiological levels seen in individuals who smoke.
Elsevier