Progress in osteoporosis has been stultified by repetitive, statistic-driven studies and
catechistic reviews; in the absence of concept and hypothesis research is aimless, and the
trivial associations it continually reveals, has led to the cul-de-sac of multifactorialism. A
return to hypothesis-led research which seeks major causal defects and the conclusive
therapies that arise from them is essential. The hypothesis proposed evolved from research
into the mechanism of senile purpura. This predicted a causal loss of skin collagen that was …