The pathway of collagen secretion
V Malhotra, P Erlmann - Annual review of cell and …, 2015 - annualreviews.org
COPII vesicles mediate export of secretory cargo from the endoplasmic reticulum (ER).
However, a standard COPII vesicle with a diameter of 60–90 nm is too small to export
collagens that are composed of rigid triple helices of up to 400 nm in length. How do cells
pack and secrete such bulky molecules? This issue is fundamentally important, as collagens
constitute approximately 25% of our dry body weight and are essential for almost all cell-cell
interactions. Recently, a potential mechanism for the biogenesis of mega-transport carriers …
However, a standard COPII vesicle with a diameter of 60–90 nm is too small to export
collagens that are composed of rigid triple helices of up to 400 nm in length. How do cells
pack and secrete such bulky molecules? This issue is fundamentally important, as collagens
constitute approximately 25% of our dry body weight and are essential for almost all cell-cell
interactions. Recently, a potential mechanism for the biogenesis of mega-transport carriers …
