CD8 T cell exhaustion during chronic viral infection and cancer
LM McLane, MS Abdel-Hakeem… - Annual review of …, 2019 - annualreviews.org
Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections
and cancers in animal models and humans. Tex cells are characterized by progressive loss
of effector functions, high and sustained inhibitory receptor expression, metabolic
dysregulation, poor memory recall and homeostatic self-renewal, and distinct transcriptional
and epigenetic programs. The ability to reinvigorate Tex cells through inhibitory receptor
blockade, such as αPD-1, highlights the therapeutic potential of targeting this population …
and cancers in animal models and humans. Tex cells are characterized by progressive loss
of effector functions, high and sustained inhibitory receptor expression, metabolic
dysregulation, poor memory recall and homeostatic self-renewal, and distinct transcriptional
and epigenetic programs. The ability to reinvigorate Tex cells through inhibitory receptor
blockade, such as αPD-1, highlights the therapeutic potential of targeting this population …
