Perfluorocarbon emulsions radiosensitise brain tumors in carbogen breathing mice with orthotopic GL261 gliomas
LA Feldman, MS Fabre, C Grasso, D Reid… - PLoS …, 2017 - journals.plos.org
LA Feldman, MS Fabre, C Grasso, D Reid, WC Broaddus, GM Lanza, BD Spiess, JR Garbow…
PLoS One, 2017•journals.plos.orgBackground Tumour hypoxia limits the effectiveness of radiation therapy. Delivering
normobaric or hyperbaric oxygen therapy elevates pO2 in both tumour and normal brain
tissue. However, pO2 levels return to baseline within 15 minutes of stopping therapy. Aim To
investigate the effect of perfluorocarbon (PFC) emulsions on hypoxia in subcutaneous and
intracranial mouse gliomas and their radiosensitising effect in orthotopic gliomas in mice
breathing carbogen (95% O2 and 5% CO2). Results PFC emulsions completely abrogated …
normobaric or hyperbaric oxygen therapy elevates pO2 in both tumour and normal brain
tissue. However, pO2 levels return to baseline within 15 minutes of stopping therapy. Aim To
investigate the effect of perfluorocarbon (PFC) emulsions on hypoxia in subcutaneous and
intracranial mouse gliomas and their radiosensitising effect in orthotopic gliomas in mice
breathing carbogen (95% O2 and 5% CO2). Results PFC emulsions completely abrogated …
Background
Tumour hypoxia limits the effectiveness of radiation therapy. Delivering normobaric or hyperbaric oxygen therapy elevates pO2 in both tumour and normal brain tissue. However, pO2 levels return to baseline within 15 minutes of stopping therapy.
Aim
To investigate the effect of perfluorocarbon (PFC) emulsions on hypoxia in subcutaneous and intracranial mouse gliomas and their radiosensitising effect in orthotopic gliomas in mice breathing carbogen (95%O2 and 5%CO2).
Results
PFC emulsions completely abrogated hypoxia in both subcutaneous and intracranial GL261 models and conferred a significant survival advantage orthotopically (Mantel Cox: p = 0.048) in carbogen breathing mice injected intravenously (IV) with PFC emulsions before radiation versus mice receiving radiation alone. Carbogen alone decreased hypoxia levels substantially and conferred a smaller but not statistically significant survival advantage over and above radiation alone.
Conclusion
IV injections of PFC emulsions followed by 1h carbogen breathing, radiosensitises GL261 intracranial tumors.
PLOS