Kynurenine, quinolinic acid—The new factors linked to carotid atherosclerosis in patients with end-stage renal disease
K Pawlak, S Brzosko, M Mysliwiec, D Pawlak - Atherosclerosis, 2009 - Elsevier
Increased oxidative stress (SOX), inflammation and accelerated atherosclerosis have been
reported in end-stage renal disease (ESRD), but their associations with kynurenine pathway
activation remain unknown. We determined the plasma concentrations of kynurenine (KYN),
kynurenic acid (KYNA) and quinolinic acid (QA); three distinct SOX markers: Cu/Zn
superoxide dismutase (Cu/Zn SOD), total peroxide and malondialdehyde (MDA), high
sensitivity C-reactive protein (hs CRP) as a indicator of inflammation, and intima-media …
reported in end-stage renal disease (ESRD), but their associations with kynurenine pathway
activation remain unknown. We determined the plasma concentrations of kynurenine (KYN),
kynurenic acid (KYNA) and quinolinic acid (QA); three distinct SOX markers: Cu/Zn
superoxide dismutase (Cu/Zn SOD), total peroxide and malondialdehyde (MDA), high
sensitivity C-reactive protein (hs CRP) as a indicator of inflammation, and intima-media …