New model for adenine-induced chronic renal failure in mice, and the effect of gum acacia treatment thereon: comparison with rats
Introduction This study aimed at comparing the effects of feeding mice and rats with adenine
to induce a state of chronic renal failure (CRF), and to assess the effect of treatment with
gum acacia (GA) thereon. Methods We compared the outcome, in mice, of feeding adenine
at three different doses (0.75%, 0.3%, and 0.2%, w/w). Biochemical and histopathological
studies were conducted in plasma, urine and renal homogenates from both species. Results
When mice and rats were fed adenine (0.75%, w/w), all treated rats survived the treatment …
to induce a state of chronic renal failure (CRF), and to assess the effect of treatment with
gum acacia (GA) thereon. Methods We compared the outcome, in mice, of feeding adenine
at three different doses (0.75%, 0.3%, and 0.2%, w/w). Biochemical and histopathological
studies were conducted in plasma, urine and renal homogenates from both species. Results
When mice and rats were fed adenine (0.75%, w/w), all treated rats survived the treatment …