Potent anti-tumor activity of systemically-administered IL2-expressing Salmonella correlates with decreased angiogenesis and enhanced tumor apoptosis
BK Al-Ramadi, MJ Fernandez-Cabezudo… - Clinical …, 2009 - Elsevier
Salmonella enterica serovar Typhimurium (hereafter S. typhimurium) stains have been
shown to exert a potent inhibitory effect on the growth of human and mouse tumors in
experimental models. Our laboratory has previously demonstrated that an attenuated strain
of S. typhimurium engineered to express IL2 (designated strain GIDIL2) has demonstrable
immunopotentiating properties, particularly affecting the innate arm of the immune system. In
the present study, we wished to explore the properties of IL2-expressing Salmonella as an …
shown to exert a potent inhibitory effect on the growth of human and mouse tumors in
experimental models. Our laboratory has previously demonstrated that an attenuated strain
of S. typhimurium engineered to express IL2 (designated strain GIDIL2) has demonstrable
immunopotentiating properties, particularly affecting the innate arm of the immune system. In
the present study, we wished to explore the properties of IL2-expressing Salmonella as an …