Piperlongumine analogue L50377 induces pyroptosis via ROS mediated NF-κB suppression in non-small-cell lung cancer
Q Li, L Chen, Z Dong, Y Zhao, H Deng, J Wu… - Chemico-Biological …, 2019 - Elsevier
Natural products with potent activity and less toxicity provide major sources for development
of novel anti-cancer drugs. Herein, we evaluated the effects and the underlying mechanisms
of a novel piperlongumine (PL) analogue L50377 on non-small-cell lung cancer (NSCLC)
cells. The results revealed that L50377 displayed greater potentials of suppressing cell
growth than PL. In addition, L50377 promoted cell apoptosis and pyroptosis via stimulating
reactive oxygen species (ROS) generation in NSCLC cells. More interestingly, ROS …
of novel anti-cancer drugs. Herein, we evaluated the effects and the underlying mechanisms
of a novel piperlongumine (PL) analogue L50377 on non-small-cell lung cancer (NSCLC)
cells. The results revealed that L50377 displayed greater potentials of suppressing cell
growth than PL. In addition, L50377 promoted cell apoptosis and pyroptosis via stimulating
reactive oxygen species (ROS) generation in NSCLC cells. More interestingly, ROS …
