The dopamine stabilizers (S)-(-)-(3-methanesulfonyl-phenyl)-1-propyl-piperidine [(-)-OSU6162] and 4-(3-methanesulfonylphenyl)-1-propyl-piperidine (ACR16) show …
S Natesan, KA Svensson, GE Reckless… - The Journal of …, 2006 - Elsevier
ABSTRACT “Dopamine stabilizers” are a new class of compounds that have the ability to
reverse both hypo-as well as hyperdopaminergia in vivo. This class, exemplified by the
phenylpiperidines (S)-(-)-3-(3-methanesulfonyl-phenyl)-1-propyl-piperidine [(-)-OSU6162]
and 4-(3-methanesulfonyl-phenyl)-1-propyl)-piperidine [ACR16] although lacking high in
vitro binding affinity for dopamine D 2 receptor [(-)-OSU6162, K i= 447 nM; ACR16, K i> 1
μM], shows functional actions, suggestive of their interaction. Hence, we evaluated in vivo D …
reverse both hypo-as well as hyperdopaminergia in vivo. This class, exemplified by the
phenylpiperidines (S)-(-)-3-(3-methanesulfonyl-phenyl)-1-propyl-piperidine [(-)-OSU6162]
and 4-(3-methanesulfonyl-phenyl)-1-propyl)-piperidine [ACR16] although lacking high in
vitro binding affinity for dopamine D 2 receptor [(-)-OSU6162, K i= 447 nM; ACR16, K i> 1
μM], shows functional actions, suggestive of their interaction. Hence, we evaluated in vivo D …