Type XVII collagen regulates lamellipod stability, cell motility, and signaling to Rac1 by targeting bullous pemphigoid antigen 1e to α6β4 integrin
KJ Hamill, SB Hopkinson, MF Jonkman… - Journal of Biological …, 2011 - jbc.org
Rac1 activity, polarity, lamellipodial dynamics, and directed motility are defective in
keratinocytes exhibiting deficiency in β4 integrin or knockdown of the plakin protein Bullous
Pemphigoid Antigen 1e (BPAG1e). The activity of Rac, formation of stable lamellipodia, and
directed migration are restored in β4 integrin-deficient cells by inducing expression of a
truncated form of β4 integrin, which lacks binding sites for BPAG1e and plectin. In these
same cells, BPAG1e, the truncated β4 integrin, and type XVII collagen (Col XVII), a …
keratinocytes exhibiting deficiency in β4 integrin or knockdown of the plakin protein Bullous
Pemphigoid Antigen 1e (BPAG1e). The activity of Rac, formation of stable lamellipodia, and
directed migration are restored in β4 integrin-deficient cells by inducing expression of a
truncated form of β4 integrin, which lacks binding sites for BPAG1e and plectin. In these
same cells, BPAG1e, the truncated β4 integrin, and type XVII collagen (Col XVII), a …
