[HTML][HTML] Akt3 kinase suppresses pinocytosis of low-density lipoprotein by macrophages via a novel WNK/SGK1/Cdc42 protein pathway
Fluid-phase pinocytosis of LDL by macrophages is regarded as a novel promising target to
reduce macrophage cholesterol accumulation in atherosclerotic lesions. The mechanisms of
regulation of fluid-phase pinocytosis in macrophages and, specifically, the role of Akt
kinases are poorly understood. We have found previously that increased lipoprotein uptake
via the receptor-independent process in Akt3 kinase-deficient macrophages contributes to
increased atherosclerosis in Akt3−/− mice. The mechanism by which Akt3 deficiency …
reduce macrophage cholesterol accumulation in atherosclerotic lesions. The mechanisms of
regulation of fluid-phase pinocytosis in macrophages and, specifically, the role of Akt
kinases are poorly understood. We have found previously that increased lipoprotein uptake
via the receptor-independent process in Akt3 kinase-deficient macrophages contributes to
increased atherosclerosis in Akt3−/− mice. The mechanism by which Akt3 deficiency …