Applications of post-translational modifications of FoxO family proteins in biological functions
Y Zhao, Y Wang, WG Zhu - Journal of molecular cell biology, 2011 - academic.oup.com
Y Zhao, Y Wang, WG Zhu
Journal of molecular cell biology, 2011•academic.oup.comThe functions of the FoxO family proteins, in particular their transcriptional activities, are
modulated by post-translational modifications (PTMs), including phosphorylation,
acetylation, ubiquitination, methylation and glycosylation. These PTMs occur in response to
different cellular stresses, which in turn regulate the subcellular localization of FoxO family
proteins, as well as their half-life, DNA binding, transcriptional activity and ability to interact
with other cellular proteins. In this review, we summarize the role of PTMs of FoxO family …
modulated by post-translational modifications (PTMs), including phosphorylation,
acetylation, ubiquitination, methylation and glycosylation. These PTMs occur in response to
different cellular stresses, which in turn regulate the subcellular localization of FoxO family
proteins, as well as their half-life, DNA binding, transcriptional activity and ability to interact
with other cellular proteins. In this review, we summarize the role of PTMs of FoxO family …
Abstract
The functions of the FoxO family proteins, in particular their transcriptional activities, are modulated by post-translational modifications (PTMs), including phosphorylation, acetylation, ubiquitination, methylation and glycosylation. These PTMs occur in response to different cellular stresses, which in turn regulate the subcellular localization of FoxO family proteins, as well as their half-life, DNA binding, transcriptional activity and ability to interact with other cellular proteins. In this review, we summarize the role of PTMs of FoxO family proteins in linking their biological and functional relevance with various diseases.
Oxford University Press