[HTML][HTML] WNK1 activates SGK1 by a phosphatidylinositol 3-kinase-dependent and non-catalytic mechanism
B Xu, S Stippec, A Lazrak, CL Huang… - Journal of Biological …, 2005 - ASBMB
WNK1 (with no lysine (K) 1) is a protein-serine/threonine kinase with a unique catalytic site
organization. Deletions in the first intron of the WNK1 gene were found in a group of
hypertensive patients with pseudohypoaldosteronism type II. No changes in coding
sequence of WNK1 were found, but its expression was increased severalfold. We have been
investigating actions of WNK1 and have found that WNK1 activates the serum-and
glucocorticoid-induced protein kinase SGK1, which impacts membrane expression of the …
organization. Deletions in the first intron of the WNK1 gene were found in a group of
hypertensive patients with pseudohypoaldosteronism type II. No changes in coding
sequence of WNK1 were found, but its expression was increased severalfold. We have been
investigating actions of WNK1 and have found that WNK1 activates the serum-and
glucocorticoid-induced protein kinase SGK1, which impacts membrane expression of the …