[HTML][HTML] Complement C5b-9 membrane attack complex increases expression of endoplasmic reticulum stress proteins in glomerular epithelial cells
AV Cybulsky, T Takano, J Papillon, A Khadir… - Journal of Biological …, 2002 - ASBMB
In the passive Heymann nephritis (PHN) model of membranous nephropathy, complement
C5b-9 induces glomerular epithelial cell (GEC) injury, proteinuria, and activation of cytosolic
phospholipase A 2 (cPLA 2). This study addresses the role of endoplasmic reticulum (ER)
stress proteins (bip, grp94) in GEC injury. GEC that overexpress cPLA 2 (produced by
transfection) and" neo" GEC (which expresses cPLA 2 at a lower level) were incubated with
complement (40 min), and leakage of constitutively expressed bip and grp94 from ER into …
C5b-9 induces glomerular epithelial cell (GEC) injury, proteinuria, and activation of cytosolic
phospholipase A 2 (cPLA 2). This study addresses the role of endoplasmic reticulum (ER)
stress proteins (bip, grp94) in GEC injury. GEC that overexpress cPLA 2 (produced by
transfection) and" neo" GEC (which expresses cPLA 2 at a lower level) were incubated with
complement (40 min), and leakage of constitutively expressed bip and grp94 from ER into …