[HTML][HTML] Role of the endoplasmic reticulum unfolded protein response in glomerular epithelial cell injury
AV Cybulsky, T Takano, J Papillon, K Bijian - Journal of Biological …, 2005 - ASBMB
C5b-9-induced glomerular epithelial cell (GEC) injury in vivo (in passive Heymann nephritis)
and in culture is associated with damage to the endoplasmic reticulum (ER) and increased
expression of ER stress proteins. Induction of ER stress proteins is enhanced via cytosolic
phospholipase A 2 (cPLA 2) and limits complement-dependent cytotoxicity. The present
study addresses another aspect of the ER unfolded protein response, ie activation of protein
kinase R-like ER kinase (PERK or pancreatic ER kinase), which phosphorylates eukaryotic …
and in culture is associated with damage to the endoplasmic reticulum (ER) and increased
expression of ER stress proteins. Induction of ER stress proteins is enhanced via cytosolic
phospholipase A 2 (cPLA 2) and limits complement-dependent cytotoxicity. The present
study addresses another aspect of the ER unfolded protein response, ie activation of protein
kinase R-like ER kinase (PERK or pancreatic ER kinase), which phosphorylates eukaryotic …