Opportunities and challenges of genotyping patients with nephrotic syndrome in the genomic era
MG Sampson, MR Pollak - Seminars in nephrology, 2015 - Elsevier
Both targeted and genome-wide linkage and association studies have identified a number of
genes and genetic variants associated with nephrotic syndrome (NS). Genotype–phenotype
studies of patients with these variants have identified correlations of clear clinical
significance. Combined with improved genomic technologies, this has resulted in
increasing, and justifiable, enthusiasm for incorporating our patients' genomic information
into our clinical management decisions. Here, we summarize our understanding of NS …
genes and genetic variants associated with nephrotic syndrome (NS). Genotype–phenotype
studies of patients with these variants have identified correlations of clear clinical
significance. Combined with improved genomic technologies, this has resulted in
increasing, and justifiable, enthusiasm for incorporating our patients' genomic information
into our clinical management decisions. Here, we summarize our understanding of NS …