A phase I study of recombinant human C1 inhibitor in asymptomatic patients with hereditary angioedema
MBA Van Doorn, J Burggraaf, T van Dam… - Journal of allergy and …, 2005 - Elsevier
BACKGROUND: Hereditary angioedema (HAE) is a congenital disorder with recurrent
attacks of localized swelling of submucosal tissue, subcutaneous tissue, or both caused by a
deficiency of the plasma protein C1 inhibitor (C1 esterase inhibitor [C1INH]). OBJECTIVE:
We sought to evaluate the effects of recombinant human C1INH (rhC1INH) isolated from the
milk of transgenic rabbits in 12 asymptomatic patients with HAE. METHODS: rhC1INH was
intravenously administered at doses of 6.25 to 100 U/kg on 2 occasions. RESULTS …
attacks of localized swelling of submucosal tissue, subcutaneous tissue, or both caused by a
deficiency of the plasma protein C1 inhibitor (C1 esterase inhibitor [C1INH]). OBJECTIVE:
We sought to evaluate the effects of recombinant human C1INH (rhC1INH) isolated from the
milk of transgenic rabbits in 12 asymptomatic patients with HAE. METHODS: rhC1INH was
intravenously administered at doses of 6.25 to 100 U/kg on 2 occasions. RESULTS …
