hERG1 channel subunit composition mediates proton inhibition of rapid delayed rectifier potassium current (IKr) in cardiomyocytes derived from hiPSCs
CU Ukachukwu, EN Jimenez-Vazquez, A Jain… - Journal of Biological …, 2023 - jbc.org
The voltage-gated channel, hERG1, conducts the rapid delayed rectifier potassium current (I
Kr) and is critical for human cardiac repolarization. Reduced I Kr causes long QT syndrome
and increases the risk for cardiac arrhythmia and sudden death. At least two subunits form
functional hERG1 channels, hERG1a and hERG1b. Changes in hERG1a/1b abundance
modulate I Kr kinetics, magnitude, and drug sensitivity. Studies from native cardiac tissue
suggest that hERG1 subunit abundance is dynamically regulated, but the impact of altered …
Kr) and is critical for human cardiac repolarization. Reduced I Kr causes long QT syndrome
and increases the risk for cardiac arrhythmia and sudden death. At least two subunits form
functional hERG1 channels, hERG1a and hERG1b. Changes in hERG1a/1b abundance
modulate I Kr kinetics, magnitude, and drug sensitivity. Studies from native cardiac tissue
suggest that hERG1 subunit abundance is dynamically regulated, but the impact of altered …