Protective and enhancing interactions among dengue viruses 1-4 and Zika virus
Dengue viruses 1-4 (DENV 1-4) and Zika virus (ZIKV) are closely related flaviviruses
transmitted by Aedes mosquitoes that co-circulate in Asia, the Americas, Africa, and
Oceania. Here, we review recent and historical literature on in vitro experiments, animal
models, and clinical and epidemiological studies to describe how the sequence of DENV 1-
4 and ZIKV infections modulates subsequent dengue and Zika disease outcome. Overall, we
find these interactions are asymmetric. Immunity from a prior DENV infection or a prior ZIKV …
transmitted by Aedes mosquitoes that co-circulate in Asia, the Americas, Africa, and
Oceania. Here, we review recent and historical literature on in vitro experiments, animal
models, and clinical and epidemiological studies to describe how the sequence of DENV 1-
4 and ZIKV infections modulates subsequent dengue and Zika disease outcome. Overall, we
find these interactions are asymmetric. Immunity from a prior DENV infection or a prior ZIKV …
