Transcriptomics of acute DENV-specific CD8+ T cells does not support qualitative differences as drivers of disease severity
While several lines of evidence suggest a protective role of T cells against disease
associated with Dengue virus (DENV) infection, their potential contribution to
immunopathology in the acute phase of DENV infection remains controversial, and it has
been hypothesized that the more severe form of the disease (dengue hemorrhagic fever,
DHF) is associated with altered T cell responses. To address this question, we determined
the transcriptomic profiles of DENV-specific CD8+ T cells in a cohort of 40 hospitalized …
associated with Dengue virus (DENV) infection, their potential contribution to
immunopathology in the acute phase of DENV infection remains controversial, and it has
been hypothesized that the more severe form of the disease (dengue hemorrhagic fever,
DHF) is associated with altered T cell responses. To address this question, we determined
the transcriptomic profiles of DENV-specific CD8+ T cells in a cohort of 40 hospitalized …
[PDF][PDF] Transcriptomics of Acute DENV-Specific CD8+ T Cells Does Not Support Qualitative Differences as Drivers of Disease Severity. Vaccines 2022, 10, 612
While several lines of evidence suggest a protective role of T cells against disease
associated with Dengue virus (DENV) infection, their potential contribution to
immunopathology in the acute phase of DENV infection remains controversial, and it has
been hypothesized that the more severe form of the disease (dengue hemorrhagic fever,
DHF) is associated with altered T cell responses. To address this question, we determined
the transcriptomic profiles of DENV-specific CD8+ T cells in a cohort of 40 hospitalized …
associated with Dengue virus (DENV) infection, their potential contribution to
immunopathology in the acute phase of DENV infection remains controversial, and it has
been hypothesized that the more severe form of the disease (dengue hemorrhagic fever,
DHF) is associated with altered T cell responses. To address this question, we determined
the transcriptomic profiles of DENV-specific CD8+ T cells in a cohort of 40 hospitalized …
