Identification of a small-molecule compound that inhibits homodimerization of oncogenic NAC1 protein and sensitizes cancer cells to anticancer agents
XH Wang, C Ji, HH Zhang, Y Shan, YJ Ren… - Journal of Biological …, 2019 - jbc.org
Nucleus accumbens–associated protein-1 (NAC1) is a transcriptional repressor encoded by
the NACC1 gene, which is amplified and overexpressed in various human cancers and
plays critical roles in tumor development, progression, and drug resistance. NAC1 has
therefore been explored as a potential therapeutic target for managing malignant tumors.
However, effective approaches for effective targeting of this nuclear protein remain elusive.
In this study, we identified a core unit consisting of Met 7 and Leu 90 in NAC1's N-terminal …
the NACC1 gene, which is amplified and overexpressed in various human cancers and
plays critical roles in tumor development, progression, and drug resistance. NAC1 has
therefore been explored as a potential therapeutic target for managing malignant tumors.
However, effective approaches for effective targeting of this nuclear protein remain elusive.
In this study, we identified a core unit consisting of Met 7 and Leu 90 in NAC1's N-terminal …
