Sexual dimorphism in the effect of maternal obesity on antioxidant defense mechanisms in the human placenta

LS Evans, L Myatt - Placenta, 2017 - Elsevier
Introduction Maternal obesity creates an adverse intrauterine environment, negatively
impacts placental respiration, is associated with a higher incidence of pregnancy
complications and programs the offspring for disease in adult life in a sexually dimorphic
manner. We defined the effect of maternal obesity and fetal sex on pro-and anti-oxidant
status in placenta and placental mitochondria. Methods: Placental villous tissue was
collected at term via c-section prior to labor from four groups of patients based on fetal sex …