Effect of folic acid on human trophoblast health and function in vitro
T Ahmed, I Fellus, J Gaudet, AJ MacFarlane… - Placenta, 2016 - Elsevier
Introduction The combined intake of folic acid (FA) from prenatal multivitamin supplements
and fortified foods can result in FA intake values that exceed the tolerable upper intake level
(UL). It is unclear what impact FA intake above the UL may have on the feto-placental unit.
Our objective was to determine the effects of increasing concentrations of FA on trophoblast
health and function in vitro. Methods Two human placental cell lines [HTR-8/SVneo (n= 5
experiments) and BeWo (n= 5 experiments)] and human placenta tissue explants (n= 6 …
and fortified foods can result in FA intake values that exceed the tolerable upper intake level
(UL). It is unclear what impact FA intake above the UL may have on the feto-placental unit.
Our objective was to determine the effects of increasing concentrations of FA on trophoblast
health and function in vitro. Methods Two human placental cell lines [HTR-8/SVneo (n= 5
experiments) and BeWo (n= 5 experiments)] and human placenta tissue explants (n= 6 …