Severe folate deficiency causes secondary depletion of choline and phosphocholine in rat liver
YI Kim, JW Miller, KA da Costa, M Nadeau, D Smith… - The Journal of …, 1994 - Elsevier
It has previously been shown that choline deficiency causes depletion of hepatic folate
concentration in rats. Two separate experiments were undertaken to investigate the
converse phenomenon: whether folate deficiency would lead to depletion of hepatic choline.
In Experiment 1, severe folate deficiency was induced in rats by feeding an amino acid-
defined diet containing (per kg diet) 1.4 g choline, 0 mg folate and 10 g
succinylsulfathiazole. Control rats were fed the same diet containing 8 mg folate/kg. After 4 …
concentration in rats. Two separate experiments were undertaken to investigate the
converse phenomenon: whether folate deficiency would lead to depletion of hepatic choline.
In Experiment 1, severe folate deficiency was induced in rats by feeding an amino acid-
defined diet containing (per kg diet) 1.4 g choline, 0 mg folate and 10 g
succinylsulfathiazole. Control rats were fed the same diet containing 8 mg folate/kg. After 4 …
